Misuse of GLP-1 Medications: Findings from a Large-Scale Study

GLP-1 (glucagon-like peptide-1 receptor agonist) medications have recently become a phenomenon in the healthcare sector. Originally developed to treat diabetes, these drugs are now widely used for weight loss, as well as the management of cardiovascular diseases and sleep apnoea. However, as their popularity grows, specialists are increasingly concerned about instances of improper use. ## Alarming Statistics According to a new study published by the U.S. Centers for Disease Control and Prevention (CDC), based on a survey conducted in the summer of 2025, approximately 9.8% of the U.S. adult population—roughly 27 million people—used GLP-1 type medications last year. Data analysis shows that nearly 44% of this group takes the drugs differently than the regimen prescribed by their physician. Patients frequently change dosages arbitrarily, skip scheduled doses, or delay prescription renewals, which calls the efficacy and safety of the treatment into question. ## Financial Barriers and Accessibility The study revealed that the primary reasons for the misuse of these medications are often financial factors and supply shortages. More than half of those surveyed stated that they were forced to alter their treatment regimen due to high costs or insufficient stock in pharmacies. This problem is particularly acute among the younger generation. Among users aged 14 to 39, 58% noted that cost-related difficulties were the main motivation for changing their treatment. In comparison, this figure is only 20% among those over the age of 65. ## Risks and Reality Experts emphasise that the self-management of GLP-1 medications carries serious risks. In addition to the fact that incorrect dosing reduces the desired treatment outcome, patients often turn to unauthorised, so-called 'unofficial' versions, the quality and composition of which are often unknown. This trend further complicates the healthcare system's efforts to ensure the safe and effective use of these powerful drugs. In Georgia, where demand for these types of products is also growing, it is critically important for patients to undergo treatment only under the supervision of a qualified physician. Arbitrary use of medications or changes in dosage, whether due to financial or other reasons, can lead to unforeseen health consequences.